Purpose Emerging evidence suggests a detrimental prognostic association between
radiation-induced lymphopenia (RIL) and pathologic response, progression-free survival …

Simple Summary Radiotherapy is as an important part of esophageal cancer (EC) treatment.
However, it often causes severe radiation-induced lymphopenia (RIL). The aim of the current …

Abstract Purpose OBP-301 (Telomelysin) is an attenuated type-5 adenovirus that contains
the human telomerase reverse transcriptase promoter to regulate viral replication. OBP-301 …

Introduction Durvalumab after concurrent chemoradiation (CCRT) for NSCLC improves
survival, but only in a subset of patients. We investigated the effect of severe radiation …

Purpose Lymphocytes play an important role in antitumor immunity; however, they are also
especially vulnerable to depletion during chemoradiation therapy (CRT). The purpose of this …

Abstract Interleukin-7 (IL-7) is an essential cytokine for T-cell homeostatic proliferation and
maintenance. Clinical studies have shown the potential benefits of IL-7 therapy in various …

Radiotherapy is a frequently utilized therapeutic modality in the treatment of esophageal
cancer (EC). Even though extensive studies are carried out in radiotherapy for EC, the …

Background The immune system plays a crucial role in cancer surveillance. Previous
studies have shown that lymphopenia associated with radiotherapy (RT) portends a poor …

Purpose The aim of this study was to determine whether radiation-induced lymphopenia
affects the survival of patients with breast cancer. Methods and Materials Post hoc analysis …

Purpose Immune system modulation, with the use of immune checkpoint inhibitors, has
drastically changed the field of oncology. Strong preclinical data indicate that radiation …