RORγt, the master transcription factor for cytokine interleukin (IL)-17, is expressed explicitly
in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans. Since …

The ubiquitylation of proteins is carried out by E1, E2 and E3 (ubiquitin ligase) enzymes, and
targets them for degradation or for other cellular fates. The HECT enzymes, including Nedd4 …

Increases in eosinophil numbers are associated with infection and allergic diseases,
including asthma, but there is also evidence that eosinophils contribute to homeostatic …

Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Background We aimed to identify novel genetic variants affecting asthma risk, since these
might provide novel insights into molecular mechanisms underlying the disease. Methods …

The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial
signaling pathways implicated in tumorigenesis is presently an area of intense research and …

Ubiquitination, the covalent attachment of ubiquitin to proteins, by E3 ligases of the HECT
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …

SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in
renal tubular cells in a manner dependent on the metabolic checkpoint kinase complex …

Twenty‐five genome‐wide association studies (GWAS) of asthma were published between
2007 and 2016, the largest with a sample size of 157242 individuals. Across these studies …

The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …