Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Populations with common physical diseases–such as cardiovascular diseases, cancer and
neurodegenerative disorders–experience substantially higher rates of major depressive …

Alzheimer's disease (AD) is caused by a complex interaction between genetic and
environmental factors. However, how the role of peripheral organ changes in response to …

Depression is frequent in older individuals and is often associated with cognitive impairment
and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative …

In adulthood, stress exposure and genetic risk heighten psychological vulnerability by
accelerating neurobiological senescence. To investigate whether molecular and brain …

How excessive stress and cortisol exposure predispose people to clinical Alzheimer's
disease (AD) is a matter of great potential medical impact. We discuss recent findings …

Abstract Neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD) constitute
multifaceted behavioral manifestations that reflect processes of emotional regulation …

Previous studies on the complex interplay between depression and dementia in patients
with Alzheimer's disease revealed that early‑life depression is a risk factor for dementia …

Depressive symptoms may either be a risk factor or prodromal to dementia. Investigating this
association in midlife may help clarify the role of depression in cognitive aging. We aimed to …

Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past
decades, a link between two disease entities has received extensive acknowledgment, yet …