Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer

M Kundu, R Butti, VK Panda, D Malhotra, S Das… - Molecular Cancer, 2024 - Springer
Breast cancer, the most frequent female malignancy, is often curable when detected at an
early stage. The treatment of metastatic breast cancer is more challenging and may be …

Integrating single-cell and bulk transcriptomic analyses to develop a cancer-associated fibroblast-derived biomarker for predicting prognosis and therapeutic response …

C Li, L Yang, Y Zhang, Q Hou, S Wang, S Lu… - Frontiers in …, 2024 - frontiersin.org
Background Cancer-associated fibroblasts (CAFs) contribute to the progression and
treatment of breast cancer (BRCA); however, risk signatures and molecular targets based on …

Autophagy Deficiency Induced by SAT1 Potentiates Tumor Progression in Triple‐Negative Breast Cancer

W Tian, L Zhu, Y Luo, Y Tang, Q Tan, Y Zou… - Advanced …, 2024 - Wiley Online Library
Aggressive triple‐negative breast cancer (TNBC) still lacks approved targeted therapies,
requiring more exploration of its underlying mechanisms. Previous studies have suggested …

GLS as a diagnostic biomarker in breast cancer: in-silico, in-situ, and in-vitro insights

D Zhang, M Wang, X Huang, L Wang, Y Liu… - Frontiers in …, 2023 - frontiersin.org
Background Recently, a novel programmed cell death mechanism, Cuproptosis, has been
discovered and found to play an important role in the development and progression of …

[HTML][HTML] RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer

Y Luo, W Tian, D Kang, L Wu, H Tang, S Wang… - Journal of Advanced …, 2024 - Elsevier
Introduction Growing interest toward RNA modification in cancer has inspired the
exploration of gene sets related to multiple RNA modifications. However, a comprehensive …

Pyrimidine metabolism regulator-mediated molecular subtypes display tumor microenvironmental hallmarks and assist precision treatment in bladder cancer

Z Wu, X Li, Z Gu, X Xia, J Yang - Frontiers in Oncology, 2023 - frontiersin.org
Background Bladder cancer (BLCA) is a common urinary system malignancy with a
significant morbidity and death rate worldwide. Non-muscle invasive BLCA accounts for over …

The Chinese herbal prescription Kang-Gong-Yan alleviates cervicitis by modulating metabolites and gut microbiota

Y Zhao, M Yuan, X Sun, P Wang, X Meng… - Pharmaceutical …, 2024 - Taylor & Francis
Context Cervicitis is a common gynecological inflammatory disease. The Chinese herbal
prescription Kang-Gong-Yan (KGY) is clinically effective against cervicitis; however, the …

Rhodobacter sphaeroides supplementation improves defense ability of Chinese mitten crab Eriocheir sinensis against Shewanella putrefaciens infection via intestinal …

H Cao, X Zheng, C Teng, L Xu, Y Wang, C Gai… - Journal of Invertebrate …, 2024 - Elsevier
Shewanella putrefaciens is a vital bacterial pathogen implicated in serious diseases in
Chinese mitten crab Eriocheir sinensis. Yet the use of probiotics to improve the defense …

Pan-cancer analysis of pyrimidine metabolism reveals signaling pathways connections with chemoresistance role

V Ramesh, M Demirdizen, L Pinna, TK Doktor… - bioRxiv, 2023 - biorxiv.org
Deregulated nucleotide metabolism, and in particular increased pyrimidine metabolism
(PyMet), has been shown to contribute to various pathological features of cancer including …