Has ferrocene really delivered its role in accentuating the bioactivity of organic scaffolds?

B Sharma, V Kumar - Journal of medicinal chemistry, 2021 - ACS Publications
Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Concept of hybrid drugs and recent advancements in anticancer hybrids

AK Singh, A Kumar, H Singh, P Sonawane, H Paliwal… - Pharmaceuticals, 2022 - mdpi.com
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships

R Wang, H Chen, W Yan, M Zheng, T Zhang… - European Journal of …, 2020 - Elsevier
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …

Metal-containing and related polymers for biomedical applications

Y Yan, J Zhang, L Ren, C Tang - Chemical Society Reviews, 2016 - pubs.rsc.org
A survey of the most recent progress in the biomedical applications of metal-containing
polymers is given. Due to the unique optical, electrochemical, and magnetic properties, at …

Quinoline-based antimalarial hybrid compounds

S Vandekerckhove, M D'hooghe - Bioorganic & medicinal chemistry, 2015 - Elsevier
Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

Ferrocene-based compounds with antimalaria/anticancer activity

S Peter, BA Aderibigbe - Molecules, 2019 - mdpi.com
Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …

Recent advances in the synthesis, biological activities and various applications of ferrocene derivatives

FA Larik, A Saeed, TA Fattah… - Applied …, 2017 - Wiley Online Library
Ferrocene derivatives constitute an important class of organometallic compounds with not
only an extensive range of biological activities but also diverse industrial as well as material …

Ferrocene derivatives as anti-infective agents

BS Ludwig, JDG Correia, FE Kühn - Coordination Chemistry Reviews, 2019 - Elsevier
Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Current scenario of ferrocene-containing hybrids for antimalarial activity

J Xiao, Z Sun, F Kong, F Gao - European Journal of Medicinal Chemistry, 2020 - Elsevier
Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and
drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great …

Metalloantimalarials

PF Salas, C Herrmann, C Orvig - Chemical reviews, 2013 - ACS Publications
Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …