Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive squamous cell
carcinomas and is highly prevalent in Asia. Alcohol and its metabolite, acetaldehyde, are …

Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies
that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The …

Background Cytoreductive nephrectomy has been the standard of care in metastatic renal-
cell carcinoma for 20 years, supported by randomized trials and large, retrospective studies …

PURPOSE We performed an open-label randomized controlled phase III study comparing
treatment outcome and toxicity between radiotherapy (RT) with concomitant cisplatin versus …

Background ITALUNG is contributing to the European evaluation of low-dose CT (LDCT)
screening for lung cancer (LC). Methods Eligible subjects aged 55–69 years, smokers or ex …

Background Recent randomized controlled trials comparing neoadjuvant chemoradiation
plus surgery or perioperative chemotherapy plus surgery with surgery alone showed …

Lung cancer, the leading cause of cancer death worldwide, is most frequently detected
through imaging tests. In this study, we investigated serum microRNAs (miRNAs) as a …

Until the early 1960s, cancer treatment consisted primarily of surgery and radiation therapy.
Most practitioners then viewed the treatment of terminally ill cancer patients with heroic …

Background Chemotherapy is the standard of care for advanced stages of non-small-cell
lung cancer (NSCLC). TG4010 is a targeted immunotherapy based on a poxvirus (modified …

Background: Population-based data on distal cholangiocarcinoma (DCC) from the Western
world are not available, albeit essential to identify areas for improvement. This study …