Biomolecular computing systems: principles, progress and potential
Y Benenson - Nature Reviews Genetics, 2012 - nature.com
The task of information processing, or computation, can be performed by natural and man-
made'devices'. Man-made computers are made from silicon chips, whereas …
made'devices'. Man-made computers are made from silicon chips, whereas …
[图书][B] Feedback control in systems biology
C Cosentino, D Bates - 2011 - books.google.com
Like engineering systems, biological systems must also operate effectively in the presence
of internal and external uncertainty—such as genetic mutations or temperature changes, for …
of internal and external uncertainty—such as genetic mutations or temperature changes, for …
Efficient characterization of high-dimensional parameter spaces for systems biology
E Zamora-Sillero, M Hafner, A Ibig, J Stelling… - BMC systems …, 2011 - Springer
Background A biological system's robustness to mutations and its evolution are influenced
by the structure of its viable space, the region of its space of biochemical parameters where …
by the structure of its viable space, the region of its space of biochemical parameters where …
Validation and invalidation of systems biology models using robustness analysis
DG Bates, C Cosentino - IET systems biology, 2011 - IET
Robustness, the ability of a system to function correctly in the presence of both internal and
external uncertainty, has emerged as a key organising principle in many biological systems …
external uncertainty, has emerged as a key organising principle in many biological systems …
[HTML][HTML] Molecular-level tuning of cellular autonomy controls the collective behaviors of cell populations
A rigorous understanding of how multicellular behaviors arise from the actions of single cells
requires quantitative frameworks that bridge the gap between genetic circuits, the …
requires quantitative frameworks that bridge the gap between genetic circuits, the …
'Glocal'robustness analysis and model discrimination for circadian oscillators
To characterize the behavior and robustness of cellular circuits with many unknown
parameters is a major challenge for systems biology. Its difficulty rises exponentially with the …
parameters is a major challenge for systems biology. Its difficulty rises exponentially with the …
Robustness and parameter geography in post-translational modification systems
Biological systems are acknowledged to be robust to perturbations but a rigorous
understanding of this has been elusive. In a mathematical model, perturbations often exert …
understanding of this has been elusive. In a mathematical model, perturbations often exert …
Robustness analysis and behavior discrimination in enzymatic reaction networks
Characterizing the behavior and robustness of enzymatic networks with numerous variables
and unknown parameter values is a major challenge in biology, especially when some …
and unknown parameter values is a major challenge in biology, especially when some …
Continuous valuations of temporal logic specifications with applications to parameter optimization and robustness measures
Finding mathematical models satisfying a specification built from the formalization of
biological experiments, is a common task of the modeler that techniques like model …
biological experiments, is a common task of the modeler that techniques like model …
Dynamic compensation, parameter identifiability, and equivariances
ED Sontag - PLoS computational biology, 2017 - journals.plos.org
A recent paper by Karin et al. introduced a mathematical notion called dynamical
compensation (DC) of biological circuits. DC was shown to play an important role in glucose …
compensation (DC) of biological circuits. DC was shown to play an important role in glucose …