As blood flows from the portal triad to the central vein, cell-mediated depletion establishes
gradients of soluble factors such as oxygen, nutrients, and hormones, which act through …

Liver resection causes marked perfusion alterations in the liver remnant both on the organ
scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level) …

In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility
to liver failure varies across individuals and is influenced by factors such as health status …

In vitro to in vivo extrapolation represents a critical challenge in toxicology. In this paper we
explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models …

The function of the liver depends critically on its blood supply. Numerous in silico models
have been developed to study various aspects of the hepatic circulation, including not only …

Advection, the transport of a substance by the flow of a fluid, is a key process in biological
systems. The energy-based bond graph approach to modelling chemical transformation …

Introduction: Physiologically based pharmacokinetic (PBPK) models for the absorption,
disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine …

The liver has a unique dual blood-supply system of hepatic arterial (HA) and portal venous
(PV) vasculatures, which are drained by a hepatic venous (HV) tree (Figure 1A). The blood …

This communication presents a mathematical mechanism-based model of the regenerating
liver after drug-induced pericentral lobule damage resolving tissue microarchitecture. The …

Liver dysfunction due to the use of hepatotoxic drugs such as paracetamol is still a problem,
especially in the long term and in high doses. Natural products derived from plants are often …