The challenge of establishing preclinical models for segmental bone defect research

JC Reichert, S Saifzadeh, ME Wullschleger, DR Epari… - Biomaterials, 2009 - Elsevier
A considerable number of international research groups as well as commercial entities work
on the development of new bone grafting materials, carriers, growth factors and specifically …

Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies

JC Reichert, DR Epari, ME Wullschleger… - … Engineering Part B …, 2010 - liebertpub.com
Currently, well-established clinical therapeutic approaches for bone reconstruction are
restricted to the transplantation of autografts and allografts, and the implantation of metal …

A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction

DS Sparks, S Saifzadeh, FM Savi, CE Dlaska… - Nature …, 2020 - nature.com
Critical-size bone defects, which require large-volume tissue reconstruction, remain a
clinical challenge. Bone engineering has the potential to provide new treatment concepts …

Biomechanical stability of novel mechanically adapted open-porous titanium scaffolds in metatarsal bone defects of sheep

J Wieding, T Lindner, P Bergschmidt, R Bader - Biomaterials, 2015 - Elsevier
Open-porous titanium scaffolds for large segmental bone defects offer advantages like early
weight-bearing and limited risk of implant failure. The objective of this experimental study …

Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep

A Berner, JC Reichert, MA Woodruff, S Saifzadeh… - Acta biomaterialia, 2013 - Elsevier
Mesenchymal progenitor cells (MPCs) represent an attractive cell population for bone tissue
engineering. Their special immunological characteristics suggest that MPCs may be used in …

[PDF][PDF] The supratrochlear foramen of the humerus and its relation to the medullary canal: a potential surgical application

GK ParaskevasABDEF, B PapaziogasDEF… - Med Sci …, 2010 - researchgate.net
Background: The supratrochlear foramen of the humerus is located at the septum separating
the coronoid from the olecranon fossa. Beyond its anthropologic interest, that trait seems to …

Nonunion fracture healing: Evaluation of effectiveness of demineralized bone matrix and mesenchymal stem cells in a novel sheep bone nonunion model

B Dozza, F Salamanna, M Baleani… - Journal of tissue …, 2018 - Wiley Online Library
Nonunion treatment has a high rate of success, although recalcitrant nonunion may
determine the need for amputation. Therefore, new treatment options are continuously …

Replacement, refinement, and reduction: necessity of standardization and computational models for long bone fracture repair in animals

J Reifenrath, N Angrisani, M Lalk… - Journal of Biomedical …, 2014 - Wiley Online Library
In the field of fracture healing it is essential to know the impacts of new materials. Fracture
healing of long bones is studied in various animal models and extrapolated for use in …

Development of a bone nonunion in a noncritical segmental tibia defect model in sheep utilizing interlocking nail as an internal fixation system

AR Lozada-Gallegos, J Letechipia-Moreno… - journal of surgical …, 2013 - Elsevier
Background The bone nonunion is an important complication of bone fracture repair. The
existing models developed on small animal species prevent using osteosynthesis materials …

Temporal changes in reverse torque of locking-head screws used in the locking plate in segmental tibial defect in goat model

RM Grzeskowiak, RE Rifkin, EG Croy, RC Steiner… - Frontiers in …, 2021 - frontiersin.org
The objective of this study was to evaluate changes in peak reverse torque (PRT) of the
locking head screws that occur over time. A locking plate construct, consisting of an 8-hole …