Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit
from dormancy have never been investigated. Here we identified the full mitochondrial …

Limiting metabolic competition in the tumour microenvironment may increase the
effectiveness of immunotherapy. Owing to its crucial role in the glucose metabolism of …

Current standard-of-care (SOC) therapy for breast cancer includes targeted therapies such
as endocrine therapy for estrogen receptor-alpha (ERα) positive; anti-HER2 monoclonal …

Cancer cells must adapt their metabolism to meet the energetic and biosynthetic demands
that accompany rapid growth of the primary tumor and colonization of distinct metastatic …

Background Metabolic plasticity has been increasingly thought to be a determinant of tumor
growth and metastasis. MACC1, a transcriptional regulator of MET, was recognized as an …

Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic
and characterized by early recurrence. Lipid metabolism is generally deregulated in TNBC …

Certain subtypes of cancer cells require oxidative phosphorylation (OXPHOS) to survive.
Increased OXPHOS dependency is frequently a hallmark of cancer stem cells and cells …

Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a
variety of fuels that facilitate tumor progression and metastasis. The significance of …