[HTML][HTML] LDL-cholesterol control in the primary prevention of cardiovascular diseases: An expert opinion for clinicians and health professionals

A Poli, AL Catapano, A Corsini, E Manzato… - Nutrition, Metabolism …, 2023 - Elsevier
Aims. Although adequate clinical management of patients with hypercholesterolemia without
a history of known cardiovascular disease is essential for prevention, these subjects are …

[HTML][HTML] Lipoprotein (a): Role in atherosclerosis and new treatment options

DT Naglic, M Manojlovic, S Pejakovic… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
Atherosclerosis is a chronic process characterized by inflammation and the progressive
accumulation of inflammatory cells and lipids in the blood vessel wall, resulting in narrowing …

Incidence of atherosclerotic cardiovascular disease in young adults at low short-term but high long-term risk

J An, Y Zhang, H Zhou, M Zhou, MM Safford… - Journal of the American …, 2023 - jacc.org
Background Young adults may have high long-term atherosclerotic cardiovascular disease
(ASCVD) risk despite low short-term risk. Objectives In this study, we sought to compare the …

Atorvastatin can modulate DNA damage repair in endothelial cells exposed to mitomycin C

M Sinitsky, M Asanov, A Sinitskaya… - International Journal of …, 2023 - mdpi.com
HMG-CoA reductase inhibitors (statins) are widely used in the therapy of atherosclerosis
and have a number of pleiotropic effects, including DNA repair regulation. We studied the …

The Complementary Effects of Dabigatran Etexilate and Exercise Training on the Development and Stability of the Atherosclerotic Lesions in Diabetic ApoE Knockout …

NPE Kadoglou, M Stasinopoulou, E Gkougkoudi… - Pharmaceuticals, 2023 - mdpi.com
Aim: To determine the complementary effects of dabigatran etexilate (DE), exercise training
(ET), and combination (DE+ ET) on the development and stability of the atherosclerotic …

Genome-wide association study of therapeutic response to statin drugs in cardiovascular disease

H Dabiri, Z Mortezaei - Scientific Reports, 2024 - nature.com
Cardiovascular disease (CVD) is one of the main causes of death in the world. The
increased level of blood cholesterol is significantly correlated to CVD incidents. Statins are a …

[HTML][HTML] Moderate-intensity rosuvastatin/ezetimibe combination versus quadruple-dose rosuvastatin monotherapy: a meta-analysis and systemic review

Y Kang, JM Park, SH Lee - Yonsei Medical Journal, 2024 - ncbi.nlm.nih.gov
Purpose There are few studies in the literature on the dosage of statin that equivalently
reduces low-density lipoprotein cholesterol (LDL-C) compared to an ezetimibe combination …

With Current Safety and Efficacy Data, Should Statins Be Made Available as Nonprescription Over-the-Counter Drugs?

A Mehta, DL Dixon, A Saeed, MS Kelly, M Gulati… - Current cardiology …, 2023 - Springer
Abstract Purpose of Review Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme
A reductase in the liver and reduce atherosclerotic cardiovascular disease (ASCVD) risk by …

Impact of CYP2C19 Gene Variants on Long-Term Treatment with Atorvastatin in Patients with Acute Coronary Syndromes

D Čereškevičius, V Zabiela, A Aldujeli… - International Journal of …, 2024 - mdpi.com
The effectiveness of lipid-lowering therapies may be insufficient in high-risk cardiovascular
patients and depends on the genetic variability of drug-metabolizing enzymes. Customizing …

Continuous Positive Airway Pressure but Not GLP1-mediated Weight Loss Improves Early Cardiovascular Disease in Obstructive Sleep Apnea: A Randomized Proof …

C O'Donnell, S Crilly, A O'Mahony… - Annals of the …, 2024 - atsjournals.org
Rationale: Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular
(CV) morbidity and mortality, but the benefit of continuous positive airway pressure (CPAP) …