[HTML][HTML] Individual differences in computational psychiatry: A review of current challenges

P Karvelis, MP Paulus, AO Diaconescu - Neuroscience & Biobehavioral …, 2023 - Elsevier
Bringing precision to the understanding and treatment of mental disorders requires
instruments for studying clinically relevant individual differences. One promising approach is …

Origins and consequences of mood flexibility: a computational perspective

M Pessiglione, R Heerema, J Daunizeau… - … & Biobehavioral Reviews, 2023 - Elsevier
A stable and neutral mood (euthymia) is commended by both economic and clinical
perspectives, because it enables rational decisions and avoids mental illnesses. Here we …

A primer on the use of computational modelling to investigate affective states, affective disorders and animal welfare in non-human animals

V Neville, M Mendl, ES Paul, P Seriès… - Cognitive, Affective, & …, 2024 - Springer
Objective measures of animal emotion-like and mood-like states are essential for preclinical
studies of affective disorders and for assessing the welfare of laboratory and other animals …

Effort Foraging Task reveals positive correlation between individual differences in the cost of cognitive and physical effort in humans

LA Bustamante, T Oshinowo, JR Lee… - Proceedings of the …, 2023 - National Acad Sciences
Effort-based decisions, in which people weigh potential future rewards against effort costs
required to achieve those rewards involve both cognitive and physical effort, though the …

Value estimation versus effort mobilization: a general dissociation between ventromedial and dorsomedial prefrontal cortex

N Clairis, M Pessiglione - Journal of Neuroscience, 2024 - Soc Neuroscience
Deciding on a course of action requires both an accurate estimation of option values and the
right amount of effort invested in deliberation to reach sufficient confidence in the final …

Social motivation in schizophrenia: What's effort got to do with it?

LT Catalano, MF Green - Schizophrenia Bulletin, 2023 - academic.oup.com
Abstract Background and Hypothesis Social motivation, defined as the fundamental human
desire to seek out, engage in, and maintain interpersonal bonds, has become a growing …

Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice

L Madur, C Ineichen, G Bergamini, A Greter… - Communications …, 2023 - nature.com
Reduced reward interest/learning and reward-to-effort valuation are distinct, common
symptoms in neuropsychiatric disorders for which chronic stress is a major aetiological …

Mood fluctuations shift cost–benefit tradeoffs in economic decisions

R Heerema, P Carrillo, J Daunizeau, F Vinckier… - Scientific Reports, 2023 - nature.com
Mood effects on economic choice seem blatantly irrational, but might rise from mechanisms
adapted to natural environments. We have proposed a theory in which mood helps adapting …

Dissociation of Cognitive Effort–Based Decision Making and Its Associations With Symptoms, Cognition, and Everyday Life Function Across Schizophrenia, Bipolar …

DM Barch, AJ Culbreth, DB Zeev, A Campbell… - Biological …, 2023 - Elsevier
Background Anhedonia and amotivation are symptoms of many different mental health
disorders that are frequently associated with functional disability, but it is not clear whether …

[HTML][HTML] What is mental effort: a clinical perspective

N Wolpe, R Holton, PC Fletcher - Biological Psychiatry, 2024 - Elsevier
Although mental effort is a frequently used term, it is poorly defined and understood.
Consequently, its usage is frequently loose and potentially misleading. In neuroscience …