In this review, we provide an updated summary on colistin pharmacokinetics and
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …

Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

Polymyxins are naturally occurring cyclic lipopeptides that were discovered more than 60
years ago. They have a narrow antibacterial spectrum, which is mainly against Gram …

Antimicrobial resistance to antibiotic treatment has significantly increased during recent
years, causing this to become a worldwide public health problem. More than 70% of …

Combinations of antimicrobial agents are often used in the management of infectious
diseases. Antimicrobial agents used as part of combination therapy are often selected …

The availability of sensitive, accurate and specific analytical methods for the measurement of
polymyxins in biological fluids has enabled an understanding of the pharmacokinetics of …

Meropenem is used to manage postneurosurgical meningitis, but its population
pharmacokinetics (PPK) in plasma and cerebrospinal fluid (CSF) in this patient group are …

Purpose Despite advances in the care of patients with severe burn injury, infection-related
morbidity and mortality remain high and can potentially be reduced with antimicrobial dosing …

Highlights•Pharmacokinetics vary markedly in critically ill patients receiving
CRRT.•Prescribe initial dose of antibiotics based on volume of distribution.•Prescribe …

Limited pharmacokinetic (PK) data suggest that currently recommended pediatric dosages
of colistimethate sodium (CMS) by the Food and Drug Administration and European …