Astrocytes play a pivotal role in maintaining the central nervous system (CNS) homeostasis
and function. In response to CNS injuries and diseases, reactive astrocytes are triggered. By …

The prokineticins (PKs) were discovered approximately 20 years ago as small peptides
inducing gut contractility. Today, they are established as angiogenic, anorectic, and …

Abstract Prokineticin-2 (Prok2) is an important secreted protein likely involved in the
pathogenesis of several acute and chronic neurological diseases through currently …

Alzheimer's disease (AD) is the most common dementia worldwide and is characterized by
the presence of senile plaques by amyloid-beta (Aβ) and neurofibrillary tangles of …

Repairing the human brain remains a challenge, despite the advances in the knowledge of
inflammatory response to injuries and the discovery of adult neurogenesis. After brain injury …

After a brain lesion, highly specialized cortical astrocytes react, supporting the closure or
replacement of the damaged tissue, but fail to regulate neural plasticity. Growing evidence …

Under normal conditions, neural stem cells (NSCs or B cells) in the adult subventricular
zone (SVZ) give rise to amplifying neural progenitor cells (NPCs or C cells), which can …

Previous studies have postulated that neuroinflammation can induce two different types of
reactive astrocytes, A1 and A2. A1 astrocytes may be harmful, whereas A2 astrocytes may …

Stimulating brain tissue regeneration is a major challenge after central nervous system
(CNS) injury, such as those observed from trauma or cerebrovascular accidents. Full …

Neurogenesis in the postnatal mammalian brain is known to occur in the dentate gyrus of
the hippocampus and the subventricular zone. These neurogenic niches serve as …