In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia
protocols are well established. The current focus is on how to improve outcomes further and …

Hypoxic-ischemic encephalopathy is brain injury resulting from the loss of oxygen and blood
supply around the time of birth. It is associated with a high risk of death or disability. The only …

Cystic white matter injury is highly associated with severe neurodevelopmental disability
and cerebral palsy in preterm infants, yet its pathogenesis remains poorly understood and …

Background Therapeutic hypothermia significantly improves outcomes after moderate–
severe hypoxic-ischemic encephalopathy (HIE), but it is partially effective. Although …

Importance Compared with normothermia, hypothermia has been shown to reduce death or
disability in neonatal hypoxic ischemic encephalopathy but data on seizures during …

It is widely suggested in neonatal rodent studies that sex critically modulates the impact of
many neuroprotective interventions, such as therapeutic hypothermia. 1 Individual studies …

Background The optimal rate to rewarm infants after therapeutic hypothermia is unclear. In
this study we examined whether slow rewarming after 72 h of hypothermia would attenuate …

Therapeutic hypothermia for hypoxic-ischaemic encephalopathy provides partial white
matter protection. Recombinant erythropoietin reduces demyelination after hypoxia …

Neonatal hypoxia-ischemia (nHI) disrupts hippocampal GABAergic development leading to
memory deficits in mice. Polysialic-acid neural-cell adhesion molecule (PSA-NCAM) …

Hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal morbidity and
mortality worldwide. Approximately 1 million infants born with HIE each year survive with …