Polymerization of ethylene oxide, propylene oxide, and other alkylene oxides: synthesis, novel polymer architectures, and bioconjugation

J Herzberger, K Niederer, H Pohlit, J Seiwert… - Chemical …, 2016 - ACS Publications
The review summarizes current trends and developments in the polymerization of alkylene
oxides in the last two decades since 1995, with a particular focus on the most important …

Delivery of therapeutic proteins

DS Pisal, MP Kosloski, SV Balu-Iyer - Journal of pharmaceutical sciences, 2010 - Elsevier
The safety and efficacy of protein therapeutics are limited by three interrelated
pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives …

Polymer–drug conjugation, recent achievements and general strategies

G Pasut, FM Veronese - Progress in polymer science, 2007 - Elsevier
The field of drug delivery is fast expanding and its potentials have already been proved by
the many products in the market. Among all approaches, polymer conjugation is a well …

The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics

CS Fishburn - Journal of pharmaceutical sciences, 2008 - Elsevier
Conjugation of macromolecules to polyethylene glycol (PEG) has emerged recently as an
effective strategy to alter the pharmacokinetic (PK) profiles of a variety of drugs, and thereby …

Polypeptide–polymer bioconjugates

LA Canalle, DWPM Löwik, JCM van Hest - Chemical Society Reviews, 2010 - pubs.rsc.org
Creating bioconjugates by combining polymers with peptides and proteins is an emerging
multidisciplinary field of research that has enjoyed increased attention within the scientific …

Process for protein PEGylation

D Pfister, M Morbidelli - Journal of Controlled Release, 2014 - Elsevier
PEGylation is a versatile drug delivery technique that presents a particularly wide range of
conjugation chemistry and polymer structure. The conjugated protein can be tuned to …

Interleukin‐6 trans‐signalling in chronic inflammation and cancer

J Scheller, N Ohnesorge… - Scandinavian journal of …, 2006 - Wiley Online Library
Abstract Interleukin‐6 (IL‐6) is a cytokine, which plays an important role in many chronic
inflammatory diseases. IL‐6 belongs to a family of 10 cytokines, which all act via receptor …

Solution of the structure of the TNF-TNFR2 complex

Y Mukai, T Nakamura, M Yoshikawa, Y Yoshioka… - Science …, 2010 - science.org
Tumor necrosis factor (TNF) is an inflammatory cytokine that has important roles in various
immune responses, which are mediated through its two receptors, TNF receptor 1 (TNFR1) …

Exciton–plasmon interactions in molecular spring assemblies of nanowires and wavelength-based protein detection

J Lee, P Hernandez, J Lee, AO Govorov, NA Kotov - Nature materials, 2007 - nature.com
Electronic interactions at the nanoscale represent one of the fundamental problems of
nanotechnology. Excitons and plasmons are the two most typical excited states of …

Polymer nanoparticles for smart drug delivery

D Bennet, S Kim - Application of nanotechnology in drug delivery, 2014 - books.google.com
In the recent decades, polymers are widely used as biomaterials due to their favorable
properties such as good biocompatibility, easy design and preparation, a variety of …