Purpose: Small-molecule inhibitors have revolutionized treatment of certain genomically defined solid cancers. Despite breakthroughs in treating systemic disease, central nervous …
Fluorescent labeling of cellular substructures is commonly performed using antibody– organic dye conjugates. Organic dyes do not exhibit ideal optical properties in terms of …
F Chen, B Madajewski, K Ma, D Karassawa Zanoni… - Science …, 2019 - science.org
Accurate detection and quantification of metastases in regional lymph nodes remain a vital prognostic predictor for cancer staging and clinical outcomes. As intratumoral heterogeneity …
Despite advances by recently approved antibody‐drug conjugates in treating advanced gastric cancer patients, substantial limitations remain. Here, several key obstacles are …
The interrogation of metabolic parameters like pH in live‐cell experiments using optical super‐resolution microscopy (SRM) remains challenging. This is due to a paucity of …
Oral delivery, while a highly desirable form of nanoparticle‐drug administration, is limited by challenges associated with overcoming several biological barriers. Here, the authors study …
Osteocytes are the resident mechanosensory cells in bone. They are responsible for skeletal homeostasis and adaptation to mechanical cues. Integrin proteins play a prominent role in …