Organic–inorganic nanoflowers: from design strategy to biomedical applications

Y Liu, X Ji, Z He - Nanoscale, 2019 - pubs.rsc.org
Organic–inorganic hybrid nanoflowers (NF) with sizes or features on a nanoscale are a
class of flower-shaped nanomaterials self-assembled from metal ions and organic …

Ultrasmall core-shell silica nanoparticles for precision drug delivery in a high-grade malignant brain tumor model

R Juthani, B Madajewski, B Yoo, L Zhang… - Clinical Cancer …, 2020 - AACR
Purpose: Small-molecule inhibitors have revolutionized treatment of certain genomically
defined solid cancers. Despite breakthroughs in treating systemic disease, central nervous …

Targeted melanoma radiotherapy using ultrasmall 177Lu-labeled α-melanocyte stimulating hormone-functionalized core-shell silica nanoparticles

X Zhang, F Chen, MZ Turker, K Ma, P Zanzonico… - Biomaterials, 2020 - Elsevier
Abstract Lutetium-177 (177 Lu) radiolabeled ultrasmall (~ 6 nm dia.) fluorescent core-shell
silica nanoparticles (Cornell prime dots or C′ dots) were developed for improving efficacy …

Antibody functionalization of ultrasmall fluorescent core–shell aluminosilicate nanoparticle probes for advanced intracellular labeling and optical super resolution …

JA Erstling, N Naguib, JA Hinckley, R Lee… - Chemistry of …, 2023 - ACS Publications
Fluorescent labeling of cellular substructures is commonly performed using antibody–
organic dye conjugates. Organic dyes do not exhibit ideal optical properties in terms of …

Molecular phenotyping and image-guided surgical treatment of melanoma using spectrally distinct ultrasmall core-shell silica nanoparticles

F Chen, B Madajewski, K Ma, D Karassawa Zanoni… - Science …, 2019 - science.org
Accurate detection and quantification of metastases in regional lymph nodes remain a vital
prognostic predictor for cancer staging and clinical outcomes. As intratumoral heterogeneity …

Engineered Ultrasmall Nanoparticle Drug‐Immune Conjugates with “Hit and Run” Tumor Delivery to Eradicate Gastric Cancer

L Zhang, V Aragon‐Sanabria, A Aditya… - Advanced …, 2023 - Wiley Online Library
Despite advances by recently approved antibody‐drug conjugates in treating advanced
gastric cancer patients, substantial limitations remain. Here, several key obstacles are …

Addressing Particle Compositional Heterogeneities in Super‐Resolution‐Enhanced Live‐Cell Ratiometric pH Sensing with Ultrasmall Fluorescent Core–Shell …

R Lee, JA Erstling, JA Hinckley… - Advanced functional …, 2021 - Wiley Online Library
The interrogation of metabolic parameters like pH in live‐cell experiments using optical
super‐resolution microscopy (SRM) remains challenging. This is due to a paucity of …

Dye encapsulation in fluorescent core–shell silica nanoparticles as probed by fluorescence correlation spectroscopy

FFE Kohle, JA Hinckley… - The Journal of Physical …, 2019 - ACS Publications
Synthetic advances in the formation of ultrasmall (< 10 nm) fluorescent poly (ethylene glycol)-
coated (PEGylated) core–shell silica nanoparticles (SNPs), enabling improved particle size …

Overcoming Barriers Associated with Oral Delivery of Differently Sized Fluorescent Core‐Shell Silica Nanoparticles

JA Erstling, N Bag, TC Gardinier, FFE Kohle… - Advanced …, 2024 - Wiley Online Library
Oral delivery, while a highly desirable form of nanoparticle‐drug administration, is limited by
challenges associated with overcoming several biological barriers. Here, the authors study …

Intravital imaging of osteocyte integrin dynamics with locally injectable fluorescent nanoparticles

MD Matthews, E Cook, N Naguib, UB Wiesner… - Bone, 2023 - Elsevier
Osteocytes are the resident mechanosensory cells in bone. They are responsible for skeletal
homeostasis and adaptation to mechanical cues. Integrin proteins play a prominent role in …