Major depressive disorder is among the most common and costly of all mental health
conditions, and in the last 20 years, emotional dysfunction has been increasingly seen as …

Highlights•Emotion context insensitivity explains reduced emotional reactivity in
depression.•Several different depression-related phenomena converge with …

Background Comorbidities in mental disorders are often understood by assuming a common
cause. The network theory of mental disorders offers an alternative to this assumption by …

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic
insight into the genetic factors moderating the impact of stress can increase our …

Multiple models of aberrant emotional processing in depression have been advanced.
However, it is unclear which of these models best applies to emotional disturbances in …

Several theoretical models of aberrant emotional experiences in depression have been
suggested. These models include potentiated reactivity to negatively-valenced stimuli …

Considering that the classical categorical approach to mental disorders does not allow a
clear identification of at-risk conditions, the dimensional approach provided by the Research …

Background Mood and anxiety disorders are leading causes of disability and mortality, due
largely to their onset during adolescence and young adulthood and broader impact on …

Prenatal experiences can influence offspring physiology and behaviour through the lifespan.
Various forms of prenatal stress impair adult learning and memory function and can lead to …

Results Identification of Allele-Specific Regulatory Elements Modulated by a Glucocorticoid
Receptor Agonist in Response to Stress Using STARR-seq. We conducted an enhancer …