Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …

Blindness, although not life threatening, is a debilitating disorder for which few, if any
treatments exist. Ocular gene therapies have the potential to profoundly improve the quality …

In zebrafish, Müller glia (MG) are a source of retinal stem cells that can replenish damaged
retinal neurons and restore vision. In mammals, however, MG do not spontaneously re-enter …

Adeno-associated viral vectors (AAVs) have become popular for gene therapy, given their
many advantages, including their reduced inflammatory profile compared with that of other …

The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-
interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like …

In mammals, synchronization of the circadian pacemaker in the hypothalamus is achieved
through direct input from the eyes conveyed by intrinsically photosensitive retinal ganglion …

Key points Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a rare population
of retinal output neurons that drives subconscious physiological responses to light, eg …

Nonsyndromic recessive retinal dystrophies cause severe visual impairment due to the
death of photoreceptor and retinal pigment epithelium cells. These diseases until recently …

Achromatopsia (ACHM), also known as rod monochromatism or total color blindness, is an
autosomal recessively inherited retinal disorder that affects the cones of the retina, the type …

Alpha/Y-type retinal ganglion cells encode visual information with a receptive field
composed of nonlinear subunits. This nonlinear subunit structure enhances sensitivity to …