Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Background Several clinical trials have reported inconsistent findings for the effect of fibrates
on cardiovascular risk. We undertook a systematic review and meta-analysis to investigate …

Sodium (Na+) is the principal osmole in extracellular fluid; as such, the total body content of
Na+ and Cl-, its primary anion, determine the extracellular fluid volume. Renal excretion or …

Type 2 diabetes is characterized by both peripheral insulin resistance and reduced insulin
secretion by β-cells. The reasons for β-cell dysfunction in this disease are incompletely …

When the'lipid nephrotoxicity hypothesis' was proposed in 1982, it brought together several
disparate experimental findings in hyperlipidemia and renal disease to suggest that …

Dyslipidemia contributes to the rate of progression of atherosclerosis and chronic kidney
disease. Also, chronic kidney disease leads to the development of secondary abnormalities …

Atherosclerosis is a leading cause of cardiovascular disease worldwide, and
hypercholesterolemia is a major risk factor. Preventive treatments mainly focus on the …

There are three peroxisome proliferator-activated receptors (PPARs) subtypes which are
commonly designated PPAR alpha, PPAR gamma and PPAR beta/delta. PPAR alpha …

Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by
dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs …

BACKGROUND: Because of the major clinical and economic burden of diabetic
nephropathy, new therapeutic tools to delay its progression are needed. Recent studies …