Disruption of the physiologic balance between cell proliferation and death is a universal
feature of all cancers. In general terms, human B-cell lymphomas can be subdivided into 2 …

The BTB/POZ-ZF [Broad complex, Tramtrack, Bric à brac (BTB) or poxvirus and zinc finger
(POZ)-zinc finger] protein family comprises a diverse group of transcription factors. POZ-ZF …

Purpose To determine the safety, dosing schedules, pharmacokinetic profile, and biologic
effect of orally administered histone deacetylase inhibitor suberoylanilide hydroxamic acid …

The BCL6 proto-oncogene encodes a transcriptional repressor whose expression is
deregulated by chromosomal translocations in approximately 40% of diffuse large B-cell …

The corepressor BCOR potentiates transcriptional repression by the proto-oncoprotein
BCL6 and suppresses the transcriptional activity of a common mixed-lineage leukemia …

BCL6 encodes a transcription factor that represses genes necessary for the terminal
differentiation of lymphocytes within germinal centers, and the misregulated expression of …

Purpose To document the toxicity and activity of the histone deacetylase inhibitor
suberoylanilide hydroxamic acid (SAHA) in patients with pretreated hematologic …

Controlling osteoclastogenesis is critical to maintain physiological bone homeostasis and
prevent skeletal disorders. Although signaling activating nuclear factor of activated T cells 1 …

Although it has been well established that osteogenic differentiation of bone mesenchymal
stem cells (bMSCs) as well as osteoclastic differentiation of macrophages can be …

Abstract Interleukin 6 (IL-6) is a growth and survival factor for multiple myeloma cells. As we
report here, the IL-6–dependent human myeloma cell line INA-6 responds with a remarkably …