Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …

Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

Energy demand of neurons in brain that is covered by glucose supply from the blood is
ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative …

The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily
to ensure fuel supply to the brain. Kidneys play a role in glucose homeostasis in the body by …

Healthy kidneys filter∼ 160 g/day of glucose (∼ 30% of daily energy intake) under
euglycaemic conditions. To prevent valuable energy from being lost in the urine, the …

Background Diabetes mellitus is an important risk factor for atrial fibrillation (AF)
development. Sodium–glucose co-transporter-2 (SGLT-2) inhibitors are used for the …

SGLT2 (sodium-glucose cotransporter 2) enables glucose and sodium reabsorption in the
kidney. SGLT2-inhibitors (also known as gliflozins, which include canagliflozin …

There is very limited human renal sodium gradient-dependent glucose transporter protein
(SGLT2) mRNA and protein expression data reported in the literature. The first aim of this …

The kidneys in normoglycemic humans filter 160–180 g of glucose per day (∼ 30% of daily
calorie intake), which is reabsorbed and returned to the systemic circulation by the proximal …

Simple Summary Despite significant advances in the treatment of cancer, it remains a major
cause of death worldwide and new treatment options are constantly being sought. An …