Homocysteine–from disease biomarker to disease prevention

AD Smith, H Refsum - Journal of internal medicine, 2021 - Wiley Online Library
We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

[HTML][HTML] Hypertension and stroke: update on treatment

M Wajngarten, GS Silva - European Cardiology Review, 2019 - ncbi.nlm.nih.gov
Stroke is the second most common cause of mortality worldwide and the third most common
cause of disability. Hypertension is the most prevalent risk factor for stroke. Stroke causes …

Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar

DJA Jenkins, JD Spence, EL Giovannucci, Y Kim… - Journal of the American …, 2021 - jacc.org
This is an update of the previous 2018 systematic review and meta-analysis of vitamin and
mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New …

Homocysteine and age-associated disorders

EA Ostrakhovitch, S Tabibzadeh - Ageing research reviews, 2019 - Elsevier
There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

Nutrition and risk of stroke

JD Spence - Nutrients, 2019 - mdpi.com
Nutrition is far more important in stroke risk than most physcians suppose. Healthy lifestyle
choices reduce the risk of stroke by~ 80%, and of the factors that increase the risk of stroke …

Problem in the recent American Heart association guideline on secondary stroke prevention: B vitamins to lower homocysteine do prevent stroke

JD Spence, GJ Hankey - Stroke, 2022 - Am Heart Assoc
In this article, we discuss a problem in the most recent American Heart Association guideline
on secondary stroke prevention that apparently arose from the rules of evidence imposed on …

Association of visceral fat area and hyperuricemia in non-obese US adults: a cross-sectional study

Z Li, L Gao, X Zhong, G Feng, F Huang, S Xia - Nutrients, 2022 - mdpi.com
This study aimed to investigate the relationship between visceral fat area (VFA) and
hyperuricemia (HUA) among non-obese adults. We extracted data from 6224 US adults …

Stroke prevention in older adults: recent advances

JD Spence, MR Azarpazhooh, SC Larsson, C Bogiatzi… - Stroke, 2020 - Am Heart Assoc
The risks of stroke and dementia increase steeply with age, and both are preventable. At
present, the best way to preserve cognitive function is to prevent stroke. Therapeutic nihilism …

NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

MH Elbatreek, S Sadegh, E Anastasi, E Guney… - PLoS …, 2020 - journals.plos.org
Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10
cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves …

[HTML][HTML] The Charlson comorbidity index and short-term readmission in patients with heart failure: A retrospective cohort study

D Wei, Y Sun, R Chen, Y Meng, W Wu - Medicine, 2023 - journals.lww.com
The relationship between the Charlson comorbidity index (CCI) and short-term readmission
is as yet unknown. Therefore, we aimed to investigate whether the CCI was independently …