The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

Aim Cannabinoid receptors are components of the endocannabinoid system that affect
various physiological functions. We aim to investigate the effect of cannabinoid receptor …

Fit to Work is a formalized working dog foundational physical fitness assessment and
development program. The Penn Vet Working Dog Center developed this program to …

Hepatic cancer is widely regarded as the leading cause of cancer-related mortality
worldwide. Despite recent advances in treatment options, the prognosis of liver cancer …

Environmental pollutants have been linked to neurotoxicity and are proposed to contribute to
neurodegenerative disorders. The zebrafish model provides a high-throughput platform for …

Mice respond to a cage change (CC) with altered activity, disrupted sleep and increased
anxiety. A bi-weekly cage change is, therefore, preferred over a shorter CC interval and is …

Simple Summary The use of research animals is regulated within the EU through Directive
2010/63/EU on the protection of animals used for scientific purposes, as well as through …

Life sciences are currently facing a reproducibility crisis. Originally, the crisis was born out of
single alarming failures to reproduce findings at different times and locations. Nowadays …

One of the most controversial aspects of the use of animals in science is the production of
pain. Pain is a central ethical concern. The activation of neural pathways involved in the pain …

Biomaterial templates play a critical role in establishing and bioinstructing three-dimensional
cellular growth, proliferation and spatial morphogenetic processes that culminate in the …