Adhesion protein structure, molecular affinities, and principles of cell-cell recognition

B Honig, L Shapiro - Cell, 2020 - cell.com
The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …

Protocadherins at the crossroad of signaling pathways

A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …

Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy

S Nishiguchi, RS Kasai… - Proceedings of the …, 2023 - National Acad Sciences
Cadherin EGF LAG seven-pass G-type receptors (CELSR) cadherins, members of the
cadherin superfamily, and adhesion G-protein-coupled receptors, play a vital role in cell–cell …

Proteomic analysis of the developing mammalian brain links PCDH19 to the Wnt/β-catenin signalling pathway

R de Nys, A Gardner, C van Eyk… - Molecular …, 2024 - nature.com
Clustering Epilepsy (CE) is a neurological disorder caused by pathogenic variants of the
Protocadherin 19 (PCDH19) gene. PCDH19 encodes a protein involved in cell adhesion …

How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition

KM Goodman, PS Katsamba, R Rubinstein, G Ahlsén… - Elife, 2022 - elifesciences.org
The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms
provides diverse identities to individual vertebrate neurons and a molecular basis for self …

Cell sorting in vitro and in vivo: how are cadherins involved?

M Takeichi - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Animal tissues are composed of heterogenous cells, and their sorting into different
compartments of the tissue is a pivotal process for organogenesis. Cells accomplish sorting …

[HTML][HTML] PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

J Rakotomamonjy, L Rylaarsdam, L Fares-Taie… - Cell reports, 2023 - cell.com
Protocadherins (PCDHs) are cell adhesion molecules that regulate many essential
neurodevelopmental processes related to neuronal maturation, dendritic arbor formation …

Structure and evolution of neuronal wiring receptors and ligands

E Cortés, JS Pak, E Özkan - Developmental Dynamics, 2023 - Wiley Online Library
One of the fundamental properties of a neuronal circuit is the map of its connections. The
cellular and developmental processes that allow for the growth of axons and dendrites …

Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts

FN Arslan, É Hannezo, J Merrin, M Loose… - Current Biology, 2024 - cell.com
Metazoan development relies on the formation and remodeling of cell-cell contacts.
Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and …

Pcdh19 mediates olfactory sensory neuron coalescence during postnatal stages and regeneration

AP Martinez, AC Chung, S Huang, AJ Bisogni, Y Lin… - Iscience, 2023 - cell.com
The mouse olfactory system regenerates constantly throughout life. While genes critical for
the initial projection of olfactory sensory neurons (OSNs) to the olfactory bulb have been …