Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Endometrial cancer is the most common cancer in women with Lynch syndrome. The
identification of individuals with Lynch syndrome is desirable because they can benefit from …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

ContextThe selection of individuals for hereditary nonpolyposis colorectal cancer (HNPCC)
genetic testing is challenging. Recently, the National Cancer Institute outlined a new set of …

Background & Aims: Hereditary nonpolyposis colorectal carcinoma (HNPCC) is caused by a
mutated mismatch repair (MMR) gene. The aim of our study was to determine the cumulative …

Copy number changes and CpG methylation of various genes are hallmarks of tumor
development but are not yet widely used in diagnostic settings. The recently developed …

Diffuse gastric cancers typically present as late‐stage tumours and, as a result, the 5 year
survival rate is poor. Some gastric cancers are hereditary and these tend to be of the diffuse …

Background: According to the international criteria for hereditary non-polyposis colorectal
cancer (HNPCC) diagnostics, cancer patients with a family history or early onset of …

We applied a novel method to detect single or multiple exon deletions and amplifications in
the BRCA1 gene. The test, called multiplex ligation-dependent probe amplification (MLPA) …