Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

Muscle myosin heads, in the absence of actin, have been shown to exist in two states, the
relaxed (turnover∼ 0.05 s− 1) and super-relaxed states (SRX, 0.005 s− 1) using a simple …

A hallmark feature of myosin-II is that it can spontaneously self-assemble into bipolar
synthetic thick filaments (STFs) in low-ionic-strength buffers, thereby serving as a …

The interacting-heads motif (IHM) is a structure of myosin that has been proposed to
modulate cardiac output by occluding myosin molecules from undergoing the force …

The biochemical SRX (super-relaxed) state of myosin has been defined as a low ATPase
activity state. This state can conserve energy when the myosin is not recruited for muscle …

For decades, sarcomeric myosin heavy chain proteins were assumed to be restricted to
striated muscle where they function as molecular motors that contract muscle. However …

Myosin heavy chain 7b (MYH7b) is an evolutionarily ancient member of the sarcomeric
myosin family, which typically supports striated muscle function. However, in mammals …

Actin–myosin mediated contractile forces are crucial for many cellular functions, including
cell motility, cytokinesis, and muscle contraction. We determined the effects of ten actin …