Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide.
However, the current pharmacological approaches used to treat OA are largely palliative …

Osteoarthritis (OA) is a complex “whole joint” disease pursued by inflammatory mediators,
rather than purely a process of “wear and tear”. Besides cartilage degradation, synovitis …

Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis
(OA) results in improved patient-reported pain and function scores. Purpose: To measure the …

Synovial fluid is a viscous solution found in the cavities of synovial joints. The principal role
of synovial fluid is to reduce friction between the articular cartilages of synovial joints during …

Although the predominant mechanism of intra-articular hyaluronan (hyaluronic acid)(HA)
and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in …

Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N‐
acetyl‐d‐glucosamine and β‐glucoronic acid. It is present in the intercellular matrix of most …

Tissues must quickly recognize injury to respond to the rapid pace of microbial growth. In
skin, dermal microvascular endothelial cells must also react to danger signals from the …

Osteoarthritis (OA) is currently defined by the American College of Rheumatology as a
“heterogeneous group of conditions that leads to joint symptoms and signs which are …

Background: Hyaluronan, or hyaluronic acid (HA), is the major hydrodynamic nonprotein
component of joint synovial fluid (SF). Its unique viscoelastic properties confer remarkable …

Hyaluronic acid (HA), is a polyanionic polysaccharide that consists of N-acetyl-D-
glucosamine and β-glucoronic acid. It is most frequently referred to as hyaluronan because it …