Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …

A pivotal role for excitotoxicity in neurodegenerative diseases is gaining increasingly more
acceptance, but the underlying mechanisms through which it participates in …

The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ)
plaques and neurofibrillary tangles. To study the interaction between Aβ and tau and their …

▪ Abstract Many neurodegenerative diseases, including Alzheimer's and Parkinson's and the
transmissible spongiform encephalopathies (prion diseases), are characterized at autopsy …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by
cognitive impairments that progress to dementia and death. The earliest symptoms of AD …

Amyloid-β (Aβ) containing plaques and tau-laden neurofibrillary tangles are the defining
neuropathological features of Alzheimer's disease (AD). To better mimic this …

Proline is unique in the realm of amino acids in its ability to adopt completely distinct cis and
trans conformations, which allows it to act as a backbone switch that is controlled by prolyl …

Protein phosphorylation regulates many cellular processes by causing changes in protein
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …

Systemic inflammation is associated with sickness behaviour and signals pass from the
blood to the brain via macrophage populations associated with the brain, the perivascular …

Deletions in the neurexin-1α gene were identified in large-scale unbiased screens for copy-
number variations in patients with autism or schizophrenia. To explore the underlying …