Central mechanisms of osmosensation and systemic osmoregulation

CW Bourque - Nature Reviews Neuroscience, 2008 - nature.com
Systemic osmoregulation is a vital process whereby changes in plasma osmolality, detected
by osmoreceptors, modulate ingestive behaviour, sympathetic outflow and renal function to …

Polyunsaturated fatty acid modulation of voltage-gated ion channels

LM Boland, MM Drzewiecki - Cell biochemistry and biophysics, 2008 - Springer
Arachidonic acid (AA) was found to inhibit the function of whole-cell voltage-gated (VG)
calcium currents nearly 16 years ago. There are now numerous examples demonstrating …

Dual stretch responses of mHCN2 pacemaker channels: accelerated activation, accelerated deactivation

W Lin, U Laitko, PF Juranka, CE Morris - Biophysical journal, 2007 - cell.com
Mechanoelectric feedback in heart and smooth muscle is thought to depend on diverse
channels that afford myocytes a mechanosensitive cation conductance. Voltage-gated …

Electrophysiological properties of identified oxytocin and vasopressin neurones

WE Armstrong, RC Foehring… - Journal of …, 2019 - Wiley Online Library
To understand the contribution of intrinsic membrane properties to the different in vivo firing
patterns of oxytocin (OT) and vasopressin (VP) neurones, in vitro studies are needed, where …

Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN

W Sheng, SW Harden, Y Tan, EG Krause, CJ Frazier - Elife, 2021 - elifesciences.org
Hypothalamic oxytocinergic magnocellular neurons have a fascinating ability to release
peptide from both their axon terminals and from their dendrites. Existing data indicates that …

Osmotic activation of a Ca2+‐dependent phospholipase C pathway that regulates ∆N TRPV1‐mediated currents in rat supraoptic neurons

V Bansal, TE Fisher - Physiological Reports, 2017 - Wiley Online Library
The magnocellular neurosecretory cells (MNCs) of the hypothalamus regulate body fluid
balance by releasing the hormones vasopressin (VP) and oxytocin (OT) in an osmolality …

Dehydration increases L‐type Ca2+ current in rat supraoptic neurons

W Zhang, B Star, W Rajapaksha… - The Journal of …, 2007 - Wiley Online Library
The magnocellular neurosecretory cells of the hypothalamus (MNCs) regulate water
balance by releasing vasopressin (VP) and oxytocin (OT) as a function of plasma osmolality …

Osmotic activation of phospholipase C triggers structural adaptation in osmosensitive rat supraoptic neurons

L Shah, V Bansal, PL Rye, N Mumtaz… - The Journal of …, 2014 - Wiley Online Library
Key points Acutely isolated rat magnocellular neurosecretory cells (MNCs) display
reversible hypertrophy when exposed to hypertonic saline (325 mosmol kg− 1) for tens of …

An osmosensitive voltage‐gated K+ current in rat supraoptic neurons

W Zhang, D Wang, XH Liu, WRA Kosala… - European journal of …, 2009 - Wiley Online Library
The magnocellular neurosecretory cells of the hypothalamus (MNCs) regulate their electrical
behaviour as a function of external osmolality through changes in the activity of …

Neurophysiology of supraoptic neurons in C57/BL mice studied in three acute in vitro preparations

R Sharif-Naeini, S Ciura, TJ Stachniak, E Trudel… - Progress in brain …, 2008 - Elsevier
Osmotic control of arginine vasopressin (AVP) and oxytocin (OXT) release from
magnocellular neurosecretory cells (MNCs) of the supraoptic (SON) and paraventricular …