Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

BACKGROUND: Here, we assessed the role of cellular senescence and the senescence
associated secretory phenotype (SASP) in age-related aortic stiffening and endothelial …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Cellular senescence and the senescence‐associated secretory phenotype (SASP)
contribute to age‐related arterial dysfunction, in part, by promoting oxidative stress and …

Innate immune cells are the early responders to infection and tissue damage. They play a
critical role in the initiation and resolution of inflammation in response to insult as well as …

The management of myocardial ischemia/reperfusion (I/R) damage in the context of
reperfusion treatment remains a significant hurdle in the field of cardiovascular disorders …

Recent strides in anti-cancer therapeutics have improved longevity and led to a growing
population of cancer survivors, who are increasingly likely to die of other causes. Treatment …

We assessed the efficacy of oral supplementation with the flavanoid apigenin on arterial
function during aging and identified critical mechanisms of action. Young (6 mo) and old (27 …

Addressing the need for more equitable cardio-oncology care requires attention to existing
disparities in cardio-oncologic disease prevention and outcomes. This is particularly …