Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

Background Mild cognitive deficits are experienced by 18% of community-dwelling older
adults, many of whom do not progress to dementia. The effect of commonly used medication …

Abstract Since 1989, four Canadian Consensus Conferences on the Diagnosis and
Treatment of Dementia (CCCDTD) have provided evidence‐based dementia guidelines for …

Background: Population-based surveillance of Alzheimer's and related dementias (AD-RD)
incidence and prevalence is important for chronic disease management and health system …

Abstract The Montreal Cognitive Assessment (MoCA) is a cognitive screening instrument
developed to detect mild cognitive impairment (MCI). It is a simple 10 min paper and pencil …

Objectives To assess the usefulness of the Montreal Cognitive Assessment (Mo CA) total
score (Mo CA‐TS) and Memory Index Score (Mo CA‐MIS) in predicting conversion to A …

Background There is no cure for dementia, and no treatments exist to halt or reverse the
course of the disease. Treatments are aimed at improving cognitive and functional …

This well-established and accessible text has been completely revised in this expanded fifth
edition. Each chapter has been updated, often extensively, to reflect current thinking, and an …

In almost all tissues, including the brain, folates are required for one-carbon transfer
reactions, which are essential for the synthesis of DNA and RNA nucleotides, the …

Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is
lower than normal for a person's age, but a higher function than that that observed in a …