Phosphoinositides as membrane organizers
Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
Phosphoinositides: regulators of nervous system function in health and disease
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …
emerged as regulators of key sub-cellular processes such as membrane transport …
Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1
Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P
Mutations that cause defects in levels of the signaling lipid phosphatidylinositol 3, 5-
bisphosphate [PI (3, 5) P2] lead to profound neurodegeneration in mice. Moreover …
bisphosphate [PI (3, 5) P2] lead to profound neurodegeneration in mice. Moreover …
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
SARM1, a protein with critical NADase activity, is a central executioner in a conserved
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid …
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like
kinases) are implicated in the onset and development of Alzheimer's disease and Down …
kinases) are implicated in the onset and development of Alzheimer's disease and Down …
Charcot–Marie–Tooth neuropathies: current gene therapy advances and the route toward translation
M Stavrou, A Kagiava, I Sargiannidou… - Journal of the …, 2023 - Wiley Online Library
Abstract Charcot–Marie–Tooth (CMT) neuropathies are a group of genetically and
phenotypically heterogeneous disorders that predominantly affect the peripheral nervous …
phenotypically heterogeneous disorders that predominantly affect the peripheral nervous …
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system
A Somogyi, ED Kirkham, E Lloyd-Evans… - Journal of Cell …, 2023 - journals.biologists.com
Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …
Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these …
Phosphoinositides and vesicular membrane traffic
P Mayinger - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
Phosphoinositide lipids were initially discovered as precursors for specific second
messengers involved in signal transduction, but have now taken the center stage in …
messengers involved in signal transduction, but have now taken the center stage in …
Yunis-Varon syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase
Yunis-Varón syndrome (YVS) is an autosomal-recessive disorder with cleidocranial
dysplasia, digital anomalies, and severe neurological involvement. Enlarged vacuoles are …
dysplasia, digital anomalies, and severe neurological involvement. Enlarged vacuoles are …