Targeting tumor microenvironment for cancer therapy

C Roma-Rodrigues, R Mendes, PV Baptista… - International journal of …, 2019 - mdpi.com
Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …

Natural products for drug discovery in the 21st century: innovations for novel drug discovery

NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

[HTML][HTML] Automating drug discovery

G Schneider - Nature reviews drug discovery, 2018 - nature.com
Small-molecule drug discovery can be viewed as a challenging multidimensional problem in
which various characteristics of compounds—including efficacy, pharmacokinetics and …

Evolution of biochip technology: A review from lab-on-a-chip to organ-on-a-chip

N Azizipour, R Avazpour, DH Rosenzweig, M Sawan… - Micromachines, 2020 - mdpi.com
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel
biomedical application for microfluidic based devices has emerged in recent years and …

Could 3D models of cancer enhance drug screening?

V Brancato, JM Oliveira, VM Correlo, RL Reis… - Biomaterials, 2020 - Elsevier
Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …

Organ-on-a-chip devices advance to market

B Zhang, M Radisic - Lab on a Chip, 2017 - pubs.rsc.org
To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices

J Aleman, T Kilic, LS Mille, SR Shin, YS Zhang - Nature Protocols, 2021 - nature.com
Organs-on-chips have emerged as viable platforms for drug screening and personalized
medicine. While a wide variety of human organ-on-a-chip models have been developed …

Cyanobacteria—From the oceans to the potential biotechnological and biomedical applications

SAM Khalifa, ES Shedid, EM Saied, AR Jassbi… - Marine Drugs, 2021 - mdpi.com
Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant
source of novel, bioactive, secondary metabolites, and they are also considered an …

Recent advances on the thermal properties and applications of nanofluids: From nanomedicine to renewable energies

RR Souza, IM Gonçalves, RO Rodrigues… - Applied Thermal …, 2022 - Elsevier
The nanofluids (NFs) are known as a colloidal suspension where nanoparticles (NPs) are
dispersed in conventional base fluids (BFs). This suspension has been frequently used to …