Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …

RNA expression of a gene is determined by not only transcriptional regulation, but also post-
transcriptional regulation of RNA decay. The precise regulation of RNA stability in the cell …

Cell division cycle-associated 8 (CDCA8) is a component of chromosomal passenger
complex (CPC) that participates in mitotic regulation. Although cancer-related CDCA8 …

Background Hepatocellular carcinoma (HCC) is a major public health problem in humans.
The imbalance of mitochondrial function has been discovered to be closely related to the …

Trimethylation of histone H3 lysine 27 trimethylation (H3K27me3) may be recruited by
repressive Polycomb complexes to mediate gene silencing, which is critical for maintaining …

Cis-regulatory elements (CREs) and super cis-regulatory elements (SCREs) are non-coding
DNA regions which influence the transcription of nearby genes and play critical roles in …

Bone marrow is a complex and dynamic microenvironment that provides essential cues to
resident cells. We developed a standardized three-dimensional (3D) model to decipher …

Background IDH1/2 hotspot mutations are well known to drive oncogenic mutations in
gliomas and are well-defined in the WHO 2021 classification of central nervous system …

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant
diseases in the world. Although the somatic alterations have been fully identified, there are …

Trimethylation of histone H3 lysine 27 trimethylation (H3K27me3) may be recruited by
repressive Polycomb complexes to mediate gene silencing, which is critical for maintaining …