Lysine (Lys) residues in proteins undergo a wide range of reversible post-translational
modifications (PTMs), which can regulate enzyme activities, chromatin structure, protein …

Prime editing is a versatile genome editing tool but requires experimental optimization of the
prime editing guide RNA (pegRNA) to achieve high editing efficiency. Here we conducted a …

RNA therapeutics are a promising strategy to treat genetic diseases caused by the
overexpression or aberrant splicing of a specific protein. The field has seen major strides in …

Summary Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …

Bivalent chemical degraders provide a catalytic route to selectively degrade disease-
associated proteins. By linking target-specific ligands with E3 ubiquitin ligase recruiting …

Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …

Simple Summary Gene expression is primarily controlled at the level of transcription, largely
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …

Histone methylation reader domains are protein modules that recognize specific histone
methylation marks, such as methylated or unmethylated lysine or arginine residues on …

Reader domains that recognize methylated lysine and arginine residues on histones play a
role in the recruitment, stabilization, and regulation of chromatin regulatory proteins …

For many years, drug discovery studies in the field of epigenetics have focused mainly on
specific enzymes such as histone deacetylases (HDACs). However, recently there has been …