Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines
S Wilson, J Qi, FV Filipp - Scientific reports, 2016 - nature.com
Sequence motifs are short, recurring patterns in DNA that can mediate sequence-specific
binding for proteins such as transcription factors or DNA modifying enzymes. The androgen …
binding for proteins such as transcription factors or DNA modifying enzymes. The androgen …
MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
DG Nowak, H Cho, T Herzka, K Watrud, DV DeMarco… - Cancer discovery, 2015 - AACR
We have recently recapitulated metastasis of human PTEN/TP53–mutant prostate cancer in
the mouse using the RapidCaP system. Surprisingly, we found that this metastasis is driven …
the mouse using the RapidCaP system. Surprisingly, we found that this metastasis is driven …
[HTML][HTML] Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome
E Hoekstra, AM Das, M Swets, W Cao… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cell signaling is dependent on the balance between phosphorylation of proteins by kinases
and dephosphorylation by phosphatases. This balance if often disrupted in colorectal cancer …
and dephosphorylation by phosphatases. This balance if often disrupted in colorectal cancer …
PTP1B deficiency enables the ability of a high-fat diet to drive the invasive character of PTEN-deficient prostate cancers
Diet affects the risk and progression of prostate cancer, but the interplay between diet and
genetic alterations in this disease is not understood. Here we present genetic evidence in …
genetic alterations in this disease is not understood. Here we present genetic evidence in …
[HTML][HTML] Differences in the expression of the phosphatase PTP-1B in patients with localized prostate cancer with and without adverse pathological features
MT Bourlon, S Urbina-Ramirez… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Methods Tissue microarrays (TMAs) were constructed using RP archival specimens for
immunohistochemical staining of PTP-1B; expression was reported with a standardized …
immunohistochemical staining of PTP-1B; expression was reported with a standardized …
Clonal lineage tracing with somatic delivery of recordable barcodes reveals migration histories of metastatic prostate cancer
RN Serio, A Scheben, B Lu, DV Gargiulo… - Cancer …, 2024 - aacrjournals.org
The patterns by which primary tumors spread to metastatic sites remain poorly understood.
Here, we define patterns of metastatic seeding in prostate cancer using a novel injection …
Here, we define patterns of metastatic seeding in prostate cancer using a novel injection …
PTP1B: from metabolism to cancer
DP Labbé, ML Tremblay - Protein Tyrosine Phosphatases in Cancer, 2016 - Springer
More than 25 years after its discovery, the prototypic protein-tyrosine phosphatase, PTP1B,
remains at the forefront of research in the phosphatase field. In this chapter, we summarize …
remains at the forefront of research in the phosphatase field. In this chapter, we summarize …
[PDF][PDF] Prostate cancer patient stratification with MINING: Molecular Signatures via Nested Dictionary Learning
ME Koletou - 2019 - research-collection.ethz.ch
Personalized medicine relies heavily on the analysis of patients' omics data that are
becoming increasingly more available nowadays. More specifically, in the case of prostate …
becoming increasingly more available nowadays. More specifically, in the case of prostate …
Hormone resistance and neuroendocrine differentiation due to accumulation of genetic lesions during clonal evolution of prostate cancer
DS Mikhaylenko, GD Efremov, AV Sivkov… - Molecular Biology, 2016 - Springer
Progression of malignant tumors is largely due to clonal evolution of the primary tumor,
clones acquiring different sets of molecular genetic lesions. Lesions can confer a selective …
clones acquiring different sets of molecular genetic lesions. Lesions can confer a selective …
Étude de l'enzyme UGT2B28 et son rôle dans le cancer de la prostate
A Belledant - 2016 - library-archives.canada.ca
Contexte: L'inactivation des androgènes est majoritairement régulée par des enzymes du
métabolisme de la famille des UDP-glucuronosyltransferase (UGT). Ce procédé …
métabolisme de la famille des UDP-glucuronosyltransferase (UGT). Ce procédé …