Glutamate, as one of the most important carbon sources in the TCA cycle, is central in
metabolic processes that will subsequently influence tumor progression. Several factors can …

Identified 40 years ago, the metabotropic glutamate (mGlu) receptors play key roles in
modulating many synapses in the brain, and are still considered as important drug targets to …

The μ-opioid receptor (μOR) represents an important target of therapeutic and abused
drugs. So far, most understanding of μOR activity has focused on a subset of known signal …

Summary β-arrestins bind G protein-coupled receptors to terminate G protein signaling and
to facilitate other downstream signaling pathways. Using single-molecule fluorescence …

The metabotropic glutamate receptors (mGluRs) are family C, dimeric G protein–coupled
receptors (GPCRs), which play critical roles in synaptic transmission. Despite an increasing …

Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs),
but relatively little is known about rapid mechanisms that control signaling on the seconds …

The metabotropic glutamate receptors (mGluRs) are neuromodulatory family CG protein
coupled receptors which assemble as dimers and allosterically couple extracellular ligand …

Dimeric metabotropic glutamate receptors (mGluRs) are abundantly expressed in neurons.
In mammals, eight subunit isoforms, mGluR1-8, have been identified, forming the groups I, II …

Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the
leading monogenic cause of intellectual disability and autism. Abundant preclinical data …

Huntington's disease is a neurodegenerative disorder caused by an expanded CAG repeat
mutation in the Huntingtin (HTT) gene. The mutation impacts neuronal protein homeostasis …