Colony-stimulating factor 1 receptor (CSF1R, also known as c-FMS) is a receptor tyrosine
kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R …

Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb
large quantities of bone. Therefore, they are frequently the target of therapeutic interventions …

The mechanisms underlying bone development, repair and regeneration are reliant on the
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as
well as bone damage under pathological conditions such as osteoporosis, arthritis …

A third of the population sustains a bone fracture, and the pace of fracture healing slows with
age. The slower pace of repair is responsible for the increased morbidity in older individuals …

Erythropoietin (EPO) is a pleiotropic cytokine that classically drives erythropoiesis but can
also induce bone loss by decreasing bone formation and increasing resorption. Deletion of …

The hematoma that forms between broken fragments of bone serves as a natural fibrin
scaffold, and its removal from the defect site delays bone healing. The hypothesis of this …

Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling
for health and disease. Since the discovery of osteoclasts in 1873, the structure and function …

Objective This study aimed to explore the effect and mechanism of chondrocyte apoptosis
on the chemotaxis of osteoclast precursors (OCPs) during bone destruction. Design The …