Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Side Effects of Immune Checkpoint Blockade The wide range of immune-related adverse
effects associated with immune checkpoint blockade can complicate this effective therapy …

Over the last decade, based on the extensive development of preclinical animal studies and
clinical trials, the efficacy, and mechanisms of immunotherapy have been fully explored …

Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at
the forefront of immunotherapy for cancers of various histological types. However, such …

Objectives Most lung cancer diagnoses occur in elderly patients, who are underrepresented
in clinical trials. We present a pooled analysis of safety and efficacy in elderly patients (≥ 75 …

Introduction Retrospective studies have shown immune-related adverse events (irAEs) to be
associated with better prognosis. However, no prospective clinical trials have been …

Immune checkpoint inhibitors, including those targeting the programmed cell death
1/programmed cell death ligand 1 and cytotoxic T lymphocyte antigen 4 pathways, are …

Although the clinical development of immune checkpoint inhibitors (ICIs) therapy has
ushered in a new era of anti-tumor therapy, with sustained responses and significant …

Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …