Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …
and mechanistically distinct substrates against steep concentration gradients. Among the …
ABC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …
living organisms. The processes are usually mediated by specific transporters. One of the …
Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
[HTML][HTML] Multidrug resistance associated proteins in multidrug resistance
Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …
Response and toxicity to cytarabine therapy in leukemia and lymphoma: from dose puzzle to pharmacogenomic biomarkers
R Di Francia, S Crisci, A De Monaco, C Cafiero, A Re… - Cancers, 2021 - mdpi.com
Simple Summary In this review, the authors propose a crosswise examination of cytarabine-
related issues ranging from the spectrum of clinical activity and severe toxicities, through …
related issues ranging from the spectrum of clinical activity and severe toxicities, through …
Cancer stem cells: problems for therapy?
MR Alison, SML Lim, LJ Nicholson - The Journal of pathology, 2011 - Wiley Online Library
Many, if not all, tumours contain a sub‐population of self‐renewing and expanding stem
cells known as cancer stem cells (CSCs). The symmetric division of CSCs is one mechanism …
cells known as cancer stem cells (CSCs). The symmetric division of CSCs is one mechanism …
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
The ATP‐binding cassette (ABC) transporters are a superfamily of membrane proteins that
are best known for their ability to transport a wide variety of exogenous and endogenous …
are best known for their ability to transport a wide variety of exogenous and endogenous …
Cancer stem cells: in the line of fire
MR Alison, WR Lin, SML Lim, LJ Nicholson - Cancer treatment reviews, 2012 - Elsevier
Most tumours appear to contain a sub-population (s) of self-renewing and expanding stem
cells known as cancer stem cells (CSCs). The CSC model proposes that CSCs are at the …
cells known as cancer stem cells (CSCs). The CSC model proposes that CSCs are at the …
Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells
D Fuchs, V Daniel, M Sadeghi, G Opelz… - … and biophysical research …, 2010 - Elsevier
Leukemia stem cells are known to exhibit multidrug resistance by expression of ATP-binding
cassette (ABC) transporters which constitute transmembrane proteins capable of exporting a …
cassette (ABC) transporters which constitute transmembrane proteins capable of exporting a …
Nucleobase and nucleoside analogues: resistance and re-sensitisation at the level of pharmacokinetics, pharmacodynamics and metabolism
Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs
that, starting from the small field of paediatric oncology, in combination with other …
that, starting from the small field of paediatric oncology, in combination with other …