HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …

The first step of the human immunodeficiency virus (HIV) replication cycle—binding and
entry into the host cell—plays a major role in determining viral tropism and the ability of HIV …

Here we have generated 3D structures of glycoforms of the spike (S) glycoprotein from
SARS-CoV-2, based on reported 3D structures and glycomics data for the protein produced …

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …

The HIV-1 envelope glycoprotein (Env) trimer contains the receptor binding sites and
membrane fusion machinery that introduce the viral genome into the host cell. As the only …

HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env)
trimers that have been challenging to characterize structurally. Here, we describe the crystal …

Chemokine receptors are critical regulators of cell migration in the context of immune
surveillance, inflammation, and development. The G protein–coupled chemokine receptor …

Abstract Model-based analyses of natural selection often categorize sites into a relatively
small number of site classes. Forcing each site to belong to one of these classes places …

Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of
great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated …

Abstract Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1)
gp120 envelope glycoprotein are critical for viral evasion of antibody neutralization, and are …