Lactate and IL6 define separable paths of inflammatory metabolic adaptation
Lactate is an end point of Warburg-type metabolism found in inflammatory macrophages.
Recently, lactate was shown to modify histones of lipopolysaccharide (LPS)–activated …
Recently, lactate was shown to modify histones of lipopolysaccharide (LPS)–activated …
Macrophage variants in laboratory research: most are well done, but some are RAW
M Herb, V Schatz, K Hadrian, D Hos… - Frontiers in Cellular …, 2024 - frontiersin.org
Macrophages play a pivotal role in the innate immune response. While their most
characteristic function is phagocytosis, it is important not to solely characterize macrophages …
characteristic function is phagocytosis, it is important not to solely characterize macrophages …
Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4
PM Moraes-Vieira, MM Yore… - Proceedings of the …, 2020 - National Acad Sciences
Adipose tissue (AT) inflammation contributes to systemic insulin resistance. In obesity and
type 2 diabetes (T2D), retinol binding protein 4 (RBP4), the major retinol carrier in serum, is …
type 2 diabetes (T2D), retinol binding protein 4 (RBP4), the major retinol carrier in serum, is …
Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation
BMDMs are a key model system to study macrophage biology in vitro. Commonly used
methods to differentiate macrophages from BM are treatment with either recombinant M-CSF …
methods to differentiate macrophages from BM are treatment with either recombinant M-CSF …
Differential effects of macrophage subtype‐specific cytokines on fibroblast proliferation and endothelial cell function in co‐culture system
Macrophages are involved in several critical activities associated with tissue repair and
regeneration. Current approaches in regenerative medicine are focusing on leveraging the …
regeneration. Current approaches in regenerative medicine are focusing on leveraging the …
Leptin signaling suppression in macrophages improves immunometabolic outcomes in obesity
Obesity is a major concern for global health care systems. Systemic low-grade inflammation
in obesity is a major risk factor for insulin resistance. Leptin is an adipokine secreted by the …
in obesity is a major risk factor for insulin resistance. Leptin is an adipokine secreted by the …
NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection
RNASeq analysis of PBMCs from treatment naïve TB patients and healthy controls revealed
that M. tuberculosis (Mtb) infection dysregulates several metabolic pathways and …
that M. tuberculosis (Mtb) infection dysregulates several metabolic pathways and …
Tumor-Associated Senescent Macrophages, Their Markers, and Their Role in Tumor Microenvironment
TV Pukhalskaia, TR Yurakova, DA Bogdanova… - Biochemistry …, 2024 - Springer
Tumor-associated macrophages (TAMs) are an important component of the tumor
microenvironment (TME) and the most abundant population of immune cells infiltrating a …
microenvironment (TME) and the most abundant population of immune cells infiltrating a …
Protection of quiescence and longevity of IgG memory B cells by mitochondrial autophagy
The development of long-lived immune memory cells against pathogens is critical for the
success of vaccines to establish protection against future infections. However, the …
success of vaccines to establish protection against future infections. However, the …
Glycyrol alleviates osteoporosis through dual modulation on osteoclastogenesis and osteogenesis by targeting Syk signaling pathway
L Tan, Y Tu, Z Miao, Y Zhao, Y Liang, J Zhong… - Phytomedicine, 2025 - Elsevier
Background Osteoporosis, characterized by an imbalance between osteoclast-mediated
bone resorption and osteoblast-mediated bone formation, has become a serious public …
bone resorption and osteoblast-mediated bone formation, has become a serious public …