▪ Abstract As the basic unit of life, the cell is a biologically complex system, the
understanding of which requires a combination of various approaches including …

Fc γ receptors (FcγR) expressed on the surface of human leukocytes bind clusters of
immunoglobulin G (IgG) to induce a variety of responses. Many therapeutic antibodies and …

Distinct genes encode 6 human receptors for IgG (hFcγRs), 3 of which have 2 or 3
polymorphic variants. The specificity and affinity of individual hFcγRs for the 4 human IgG …

Fcγ receptors (FcγRs) are expressed on all immunologically active cells. They bind the Fc
portion of IgG, thereby triggering a range of immunological functions. We have used surface …

Autoimmune diseases (ADs) showcase the intricate balance between the immune system's
protective functions and its potential for self-inflicted damage. These disorders arise from the …

▪ Abstract Cells in the immune and nervous systems communicate through informational
synapses. The two-dimensional chemistry underlying the process of synapse formation is …

The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the
deposition of immune complexes in organs such as the kidney. This occurs as a result of …

Surface presentation of adhesion receptors influences cell adhesion, although the
mechanisms underlying these effects are not well understood. We used a micropipette …

Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action
for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G1 monoclonal antibody …

Recognition of peptide presented by the major histocompatibility complex (pMHC) molecule
by the T‐cell receptor (TCR) determines T‐cell selection, development, differentiation, fate …