The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O2,
glucose, and other nutrients diffuse out of the choroid and then filter through a monolayer of …

Background Globally, the onset and progression of multiple human diseases are associated
with mitochondrial dysfunction and dysregulation of Ca 2+ uptake dynamics mediated by the …

Neuronal activation is fundamental to information processing by the brain and requires
mitochondrial energy metabolism. Mitochondrial Ca2+ uptake by the mitochondrial Ca2+ …

Mitochondria are vital organelles that require sophisticated homeostatic mechanisms for
maintenance. Intercellular transfer of damaged mitochondria is a recently identified strategy …

Optical methods for measuring intracellular ions including Ca 2+ revolutionized our
understanding of signal transduction. However, these methods are not extensively applied …

Calcium signaling is essential for regulating many biological processes. Endoplasmic
reticulum inositol trisphosphate receptors (IP 3 Rs) and the mitochondrial Ca 2+ uniporter …

Zebrafish are an instrumental system for the generation of photoreceptor degeneration
models, which can be utilized to determine underlying causes of photoreceptor dysfunction …

Calcium is a major regulator of cellular metabolism. Calcium controls mitochondrial
respiration, and calcium signaling is used to meet cellular energetic demands through …

Alzheimer's disease (AD) is a progressive and degenerative disorder accompanied by
cognitive decline, which could be promoted by mitochondrial dysfunction induced by …

Cancer cells have increased energy requirements due to their enhanced proliferation
activity. This energy demand is, among others, met by mitochondrial ATP production. Since …