Fibroblast growth factor signalling in the diseased nervous system

L Klimaschewski, P Claus - Molecular Neurobiology, 2021 - Springer
Fibroblast growth factors (FGFs) act as key signalling molecules in brain development,
maintenance, and repair. They influence the intricate relationship between myelinating cells …

New developments in the biology of fibroblast growth factors

DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury

A Aljović, A Jacobi, M Marcantoni, F Kagerer… - EMBO Molecular …, 2023 - embopress.org
Functional recovery following incomplete spinal cord injury (SCI) depends on the rewiring of
motor circuits during which supraspinal connections form new contacts onto spinal relay …

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

X Wang, L Zhu, J Hu, R Guo, S Ye, F Liu… - Frontiers in …, 2020 - frontiersin.org
Major depressive disorder is a serious neuropsychiatric disorder with high rates of
recurrence and mortality. Many studies have supported that inflammatory processes play a …

Fibroblast growth factors in depression

Z Deng, S Deng, MR Zhang, MM Tang - Frontiers in pharmacology, 2019 - frontiersin.org
Major depressive disorder (MDD) is one of the most serious diseases and now becomes a
major public health problem in the world. The pathogenesis of depression remains poorly …

Fibroblast growth factor signaling in axons: from development to disease

D Tomé, MS Dias, J Correia, RD Almeida - Cell Communication and …, 2023 - Springer
The fibroblast growth factor (FGF) family regulates various and important aspects of nervous
system development, ranging from the well-established roles in neuronal patterning to more …

Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the …

A Terauchi, EM Johnson-Venkatesh, B Bullock… - Elife, 2016 - elifesciences.org
Communication between pre-and postsynaptic cells promotes the initial organization of
synaptic specializations, but subsequent synaptic stabilization requires transcriptional …

[HTML][HTML] FGF binding proteins (FGFBPs): modulators of FGF signaling in the developing, adult, and stressed nervous system

T Taetzsch, VL Brayman, G Valdez - … Acta (BBA)-molecular basis of Disease, 2018 - Elsevier
Members of the fibroblast growth factor (FGF) family are involved in a variety of cellular
processes. In the nervous system, they affect the differentiation and migration of neurons, the …

Identification of rare copy number variants associated with pulmonary atresia with ventricular septal defect

H Xie, N Hong, E Zhang, F Li, K Sun, Y Yu - Frontiers in genetics, 2019 - frontiersin.org
Copy number variants (CNVs) are major variations contributing to the gene heterogeneity of
congenital heart diseases (CHD). pulmonary atresia with ventricular septal defect (PA-VSD) …

Fibroblast growth factor 22 is a novel modulator of depression through interleukin‐1β

YH Xu, M Yu, H Wei, S Yao, SY Chen… - CNS neuroscience & …, 2017 - Wiley Online Library
Summary Background and Aims Emerging evidence shows that fibroblast growth factor 22
(FGF 22) plays a critical role in the etiology of depression. However, the molecular …