The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope.
Lamins are involved in numerous functions, including a role in providing structural support to …

Many DNA and a few RNA viruses use the host cell nucleus for virion formation and/or
genome replication. To this end, the nuclear envelope (NE) barrier has to be overcome for …

The nuclear pore complex (NPC) has long been assumed to be the sole route across the
nuclear envelope, and under normal homeostatic conditions it is indeed the main …

The nuclear lamina is the main component of the nuclear cytoskeleton that maintains the
integrity of the nucleus. However, it represents a natural barrier for viruses replicating in the …

Viruses are obligatory intracellular parasites. For their efficient replication, many require
access to the nuclear interior. Yet, only few viral particles are small enough to passively …

Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the
following steps, including nuclear import, are inefficient, limiting their use in therapeutic …

Nuclear pores have an approximately uniform distribution in the nuclear envelope of most
living cells. Hence, the morphology of the nuclear envelope is a spherical stomatocyte with a …

The key factor of genome instability during aging is transposon dysregulation. This may be
due to senile changes in the expression of lamins, which epigenetically modulate …

Autonomic parvoviruses, small non-enveloped ssDNA viruses, encode only a limited
number of proteins, which makes them highly dependent on the functions provided by the …

Аннотация Дисбаланс активации транспозонов–один из важнейших факторов
нестабильности генома при старении. Причинами этого явления могут быть …