Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Paracrine mechanisms of mesenchymal stem cells in tissue repair

M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

Immunomodulatory effect of adipose-derived stem cells: the cutting edge of clinical application

S Ceccarelli, P Pontecorvi, E Anastasiadou… - Frontiers in cell and …, 2020 - frontiersin.org
Adipose-derived stem cells (ASCs) represent a promising tool for soft tissue engineering as
well as for clinical treatment of inflammatory and autoimmune pathologies. The well …

Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine

AJ Salgado, RL Reis, N Sousa… - Current stem cell …, 2010 - ingentaconnect.com
Stem cells have been long looked at as possible therapeutic vehicles for different health
related problems. Among the different existing stem cell populations, Adipose derived Stem …

[HTML][HTML] The stem cell secretome and its role in brain repair

D Drago, C Cossetti, N Iraci, E Gaude, G Musco… - Biochimie, 2013 - Elsevier
Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal
(MSCs) and neural/progenitor stem cells (NPCs), exert a substantial beneficial and …

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

FG Teixeira, MM Carvalho, N Sousa… - Cellular and Molecular …, 2013 - Springer
The low regeneration potential of the central nervous system (CNS) represents a challenge
for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have …

Mesenchymal stromal cell therapies for neurodegenerative diseases

NP Staff, DT Jones, W Singer - Mayo Clinic Proceedings, 2019 - Elsevier
Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

Impact of the secretome of human mesenchymal stem cells on brain structure and animal behavior in a rat model of Parkinson's disease

FG Teixeira, MM Carvalho… - Stem cells …, 2017 - academic.oup.com
Research in the last decade strongly suggests that mesenchymal stem cell (MSC)-mediated
therapeutic benefits are mainly due to their secretome, which has been proposed as a …

Exosomes and stem cells in degenerative disease diagnosis and therapy

YH Chang, KC Wu, HJ Harn, SZ Lin… - Cell …, 2018 - journals.sagepub.com
Stroke can cause death and disability, resulting in a huge burden on society. Parkinson's
disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction …

Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies

N D'souza, F Rossignoli, G Golinelli, G Grisendi… - BMC medicine, 2015 - Springer
Regenerative medicine relying on cell and gene therapies is one of the most promising
approaches to repair tissues. Multipotent mesenchymal stem/stromal cells (MSC), a …