Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

P Morigny, J Boucher, P Arner, D Langin - Nature Reviews …, 2021 - nature.com
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Cancer cachexia: understanding the molecular basis

JM Argilés, S Busquets, B Stemmler… - Nature Reviews …, 2014 - nature.com
Cancer cachexia is a devastating, multifactorial and often irreversible syndrome that affects
around 50–80% of cancer patients, depending on the tumour type, and that leads to …

Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later

AM Ryan, DG Power, L Daly, SJ Cushen… - Proceedings of the …, 2016 - cambridge.org
An awareness of the importance of nutritional status in hospital settings began more than 40
years ago. Much has been learned since and has altered care. For the past 40 years several …

Inter-tissue communication in cancer cachexia

JM Argilés, B Stemmler, FJ López-Soriano… - Nature Reviews …, 2019 - nature.com
Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Cancer cachexia: mediators, signaling, and metabolic pathways

KCH Fearon, DJ Glass, DC Guttridge - Cell metabolism, 2012 - cell.com
Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

Measurement of skeletal muscle radiation attenuation and basis of its biological variation

J Aubrey, N Esfandiari, VE Baracos… - Acta …, 2014 - Wiley Online Library
Skeletal muscle contains intramyocellular lipid droplets within the cytoplasm of myocytes as
well as intermuscular adipocytes. These depots exhibit physiological and pathological …

Muscle ultrasound and sarcopenia in older individuals: a clinical perspective

A Ticinesi, T Meschi, MV Narici, F Lauretani… - Journal of the American …, 2017 - Elsevier
Introduction A precise quantitative measurement of skeletal muscle mass is fundamental for
diagnosing sarcopenia in older individuals. The current techniques of assessment, including …

Mechanisms of metabolic dysfunction in cancer-associated cachexia

M Petruzzelli, EF Wagner - Genes & development, 2016 - genesdev.cshlp.org
Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer
patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the …

Sarcopenia: current concepts and imaging implications

RD Boutin, L Yao, RJ Canter… - American Journal of …, 2015 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this article is to review the nomenclature, clinical impact, and
diagnostic techniques characterizing sarcopenia. CONCLUSION. Sarcopenia—defined as …

Sarcopenia: diagnosis and management, state of the art and contribution of ultrasound

S Giovannini, F Brau, R Forino, A Berti… - Journal of Clinical …, 2021 - mdpi.com
Age-related muscle loss is a phenomenon that has been extensively studied in recent
decades. Sarcopenia is a multisystem disease, which predisposes to muscle weakness and …