New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
J Yuan, X Dong, J Yap, J Hu - Journal of hematology & oncology, 2020 - Springer
Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
Energy-stress-mediated AMPK activation inhibits ferroptosis
Energy stress depletes ATP and induces cell death. Here we identify an unexpected
inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron …
inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
The AMPK pathway in fatty liver disease
C Fang, J Pan, N Qu, Y Lei, J Han, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …
From pre-diabetes to diabetes: diagnosis, treatments and translational research
Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …
According to the 2017 International Diabetes Federation (IDF) statistics, the global …
AMPK: guardian of metabolism and mitochondrial homeostasis
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
AMPK and the adaptation to exercise
HR Spaulding, Z Yan - Annual review of physiology, 2022 - annualreviews.org
Noncommunicable diseases are chronic diseases that contribute to death worldwide, but
these diseases can be prevented and mitigated with regular exercise. Exercise activates …
these diseases can be prevented and mitigated with regular exercise. Exercise activates …
The mechanisms of action of metformin
Metformin is a widely-used drug that results in clear benefits in relation to glucose
metabolism and diabetes-related complications. The mechanisms underlying these benefits …
metabolism and diabetes-related complications. The mechanisms underlying these benefits …
AMPK: sensing glucose as well as cellular energy status
Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …